3MZS

Crystal Structure of Cytochrome P450 CYP11A1 in complex with 22-hydroxy-cholesterol

3MZS の概要

• エントリーDOI: 10.2210/pdb3mzs/pdb
• 分子名称: Cholesterol side-chain cleavage enzyme, PROTOPORPHYRIN IX CONTAINING FE, (3alpha,8alpha,22R)-cholest-5-ene-3,22-diol, ... (5 entities in total)
• 機能のキーワード: cyp11a1, cytochrome p450, monooxygenase, side chain cleavage enzyme, cholesterol, cholesterol 20-22-desmolase, steroid metabolism, oxidoreductase, heme
• 由来する生物種: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• 細胞内の位置: Mitochondrion membrane: P00189
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 232784.20

構造登録者

Stout, C.D.,Annalora, A.,Mast, N.,Pikuleva, I. (登録日: 2010-05-12, 公開日: 2010-12-15, 最終更新日: 2023-09-06)

• 主引用文献: Mast, N.,Annalora, A.J.,Lodowski, D.T.,Palczewski, K.,Stout, C.D.,Pikuleva, I.A.; Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1.; J.Biol.Chem., 286:5607-5613, 2011; PubMed: 21159775; DOI: 10.1074/jbc.M110.188433

実験手法

X-RAY DIFFRACTION (2.5 Å)