3MXR

SHV-1 beta-lactamase complex with compound 1

Summary for 3MXR

• Entry DOI: 10.2210/pdb3mxr/pdb
• Related: 3MKE 3MKF 3MXS
• Descriptor: Beta-lactamase SHV-1, ({[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-4-(4-hydroxyphenyl)butanoyl]amino}methyl)boronic acid, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (4 entities in total)
• Functional Keywords: beta-lactamase, boronic acid transition state inhibitor, drug design, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 30344.44

Authors

Ke, W.,van den Akker, F. (deposition date: 2010-05-07, release date: 2010-11-24, Last modification date: 2023-09-06)

• Primary citation: Ke, W.,Sampson, J.M.,Ori, C.,Prati, F.,Drawz, S.M.,Bethel, C.R.,Bonomo, R.A.,van den Akker, F.; Novel Insights into the Mode of Inhibition of Class A SHV-1 {beta}-Lactamases Revealed by Boronic Acid Transition State Inhibitors.; Antimicrob.Agents Chemother., 55:174-183, 2011; PubMed: 21041505; DOI: 10.1128/AAC.00930-10

Experimental method

X-RAY DIFFRACTION (1.3 Å)