3MXR

SHV-1 beta-lactamase complex with compound 1

3MXR の概要

• エントリーDOI: 10.2210/pdb3mxr/pdb
• 関連するPDBエントリー: 3MKE 3MKF 3MXS
• 分子名称: Beta-lactamase SHV-1, ({[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-4-(4-hydroxyphenyl)butanoyl]amino}methyl)boronic acid, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (4 entities in total)
• 機能のキーワード: beta-lactamase, boronic acid transition state inhibitor, drug design, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30344.44

構造登録者

Ke, W.,van den Akker, F. (登録日: 2010-05-07, 公開日: 2010-11-24, 最終更新日: 2023-09-06)

• 主引用文献: Ke, W.,Sampson, J.M.,Ori, C.,Prati, F.,Drawz, S.M.,Bethel, C.R.,Bonomo, R.A.,van den Akker, F.; Novel Insights into the Mode of Inhibition of Class A SHV-1 {beta}-Lactamases Revealed by Boronic Acid Transition State Inhibitors.; Antimicrob.Agents Chemother., 55:174-183, 2011; PubMed: 21041505; DOI: 10.1128/AAC.00930-10

実験手法

X-RAY DIFFRACTION (1.3 Å)