3MWW
Crystal structure of HCV NS5B polymerase
3MWW の概要
エントリーDOI | 10.2210/pdb3mww/pdb |
関連するPDBエントリー | 3MWV |
分子名称 | Genome polyprotein, SULFATE ION, 1-[2-(4-carboxypiperidin-1-yl)-2-oxoethyl]-3-cyclohexyl-2-furan-3-yl-1H-indole-6-carboxylic acid, ... (4 entities in total) |
機能のキーワード | hcv virus rdrp ns5b polymerase inhibitor, transferase |
由来する生物種 | Hepatitis C virus (HCV) |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 129338.00 |
構造登録者 | |
主引用文献 | LaPlante, S.R.,Gillard, J.R.,Jakalian, A.,Aubry, N.,Coulombe, R.,Brochu, C.,Tsantrizos, Y.S.,Poirier, M.,Kukolj, G.,Beaulieu, P.L. Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B. J.Am.Chem.Soc., 132:15204-15212, 2010 Cited by PubMed: 20942454DOI: 10.1021/ja101358s 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.8 Å) |
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