3MTL
Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
Summary for 3MTL
Entry DOI | 10.2210/pdb3mtl/pdb |
Descriptor | Cell division protein kinase 16, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} (3 entities in total) |
Functional Keywords | pctaire1, kinase, indirubin, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q00536 |
Total number of polymer chains | 1 |
Total formula weight | 37674.17 |
Authors | Krojer, T.,Sharpe, T.D.,Roos, A.,Savitsky, P.,Amos, A.,Ayinampudi, V.,Berridge, G.,Fedorov, O.,Keates, T.,Phillips, C.,Burgess-Brown, N.,Zhang, Y.,Pike, A.C.W.,Muniz, J.,Vollmar, M.,Thangaratnarajah, C.,Rellos, P.,Ugochukwu, E.,Filippakopoulos, P.,Yue, W.,Das, S.,von Delft, F.,Edwards, A.,Arrowsmith, C.H.,Weigelt, J.,Bountra, C.,Knapp, S.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-04-30, release date: 2010-06-09, Last modification date: 2023-11-01) |
Primary citation | Dixon-Clarke, S.E.,Shehata, S.N.,Krojer, T.,Sharpe, T.D.,von Delft, F.,Sakamoto, K.,Bullock, A.N. Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16. Biochem.J., 474:699-713, 2017 Cited by PubMed: 28057719DOI: 10.1042/BCJ20160941 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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