3MTL

Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804

3MTL の概要

• エントリーDOI: 10.2210/pdb3mtl/pdb
• 分子名称: Cell division protein kinase 16, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} (3 entities in total)
• 機能のキーワード: pctaire1, kinase, indirubin, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q00536
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37674.17

構造登録者

Krojer, T.,Sharpe, T.D.,Roos, A.,Savitsky, P.,Amos, A.,Ayinampudi, V.,Berridge, G.,Fedorov, O.,Keates, T.,Phillips, C.,Burgess-Brown, N.,Zhang, Y.,Pike, A.C.W.,Muniz, J.,Vollmar, M.,Thangaratnarajah, C.,Rellos, P.,Ugochukwu, E.,Filippakopoulos, P.,Yue, W.,Das, S.,von Delft, F.,Edwards, A.,Arrowsmith, C.H.,Weigelt, J.,Bountra, C.,Knapp, S.,Bullock, A.,Structural Genomics Consortium (SGC) (登録日: 2010-04-30, 公開日: 2010-06-09, 最終更新日: 2023-11-01)

• 主引用文献: Dixon-Clarke, S.E.,Shehata, S.N.,Krojer, T.,Sharpe, T.D.,von Delft, F.,Sakamoto, K.,Bullock, A.N.; Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.; Biochem.J., 474:699-713, 2017; PubMed: 28057719; DOI: 10.1042/BCJ20160941

実験手法

X-RAY DIFFRACTION (2.4 Å)