3MRL
Crystal Structure of MHC class I HLA-A2 molecule complexed with HCV NS3-1073-1081 nonapeptide C6V variant
Summary for 3MRL
Entry DOI | 10.2210/pdb3mrl/pdb |
Related | 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRI 3MRJ 3MRK 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, 9-meric peptide from Serine protease/NTPase/helicase NS3, ... (4 entities in total) |
Functional Keywords | mhc class i, hla, immune system, immune response, nonapeptide, viral peptide, hepatitis c virus, ns3 protein |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted : P61769 Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q03463 |
Total number of polymer chains | 3 |
Total formula weight | 46878.24 |
Authors | Gras, S.,Reiser, J.-B.,Chouquet, A.,Le Gorrec, M.,Debeaupuis, E.,Echasserieau, K.,Saulquin, X.,Bonneville, M.,Housset, D. (deposition date: 2010-04-29, release date: 2011-05-25, Last modification date: 2023-11-01) |
Primary citation | Reiser, J.B.,Legoux, F.,Gras, S.,Trudel, E.,Chouquet, A.,Leger, A.,Le Gorrec, M.,Machillot, P.,Bonneville, M.,Saulquin, X.,Housset, D. Analysis of Relationships between Peptide/MHC Structural Features and Naive T Cell Frequency in Humans. J.Immunol., 193:5816-5826, 2014 Cited by PubMed: 25392532DOI: 10.4049/jimmunol.1303084 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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