3MRL

Crystal Structure of MHC class I HLA-A2 molecule complexed with HCV NS3-1073-1081 nonapeptide C6V variant

3MRL の概要

• エントリーDOI: 10.2210/pdb3mrl/pdb
• 関連するPDBエントリー: 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRI 3MRJ 3MRK 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, 9-meric peptide from Serine protease/NTPase/helicase NS3, ... (4 entities in total)
• 機能のキーワード: mhc class i, hla, immune system, immune response, nonapeptide, viral peptide, hepatitis c virus, ns3 protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted : P61769; Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q03463
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 46878.24

構造登録者

Gras, S.,Reiser, J.-B.,Chouquet, A.,Le Gorrec, M.,Debeaupuis, E.,Echasserieau, K.,Saulquin, X.,Bonneville, M.,Housset, D. (登録日: 2010-04-29, 公開日: 2011-05-25, 最終更新日: 2023-11-01)

• 主引用文献: Reiser, J.B.,Legoux, F.,Gras, S.,Trudel, E.,Chouquet, A.,Leger, A.,Le Gorrec, M.,Machillot, P.,Bonneville, M.,Saulquin, X.,Housset, D.; Analysis of Relationships between Peptide/MHC Structural Features and Naive T Cell Frequency in Humans.; J.Immunol., 193:5816-5826, 2014; PubMed: 25392532; DOI: 10.4049/jimmunol.1303084

実験手法

X-RAY DIFFRACTION (2.41 Å)