3MPT

Crystal structure of P38 kinase in complex with a pyrrole-2-carboxamide inhibitor

3MPT の概要

• エントリーDOI: 10.2210/pdb3mpt/pdb
• 分子名称: Mitogen-activated protein kinase 14, N-(furan-2-ylmethyl)-4-[(2-methylphenyl)carbonyl]-1H-pyrrole-2-carboxamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: p38, serine/threonine protein kinase, map kinase, pyrrole-2-carboxamides, inhibitor, transferase-transferase inhibiator complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43235.35

構造登録者

Somers, D.O. (登録日: 2010-04-27, 公開日: 2010-07-07, 最終更新日: 2023-09-06)

• 主引用文献: Down, K.,Bamborough, P.,Alder, C.,Campbell, A.,Christopher, J.A.,Gerelle, M.,Ludbrook, S.,Mallett, D.,Mellor, G.,Miller, D.D.,Pearson, R.,Ray, K.,Solanke, Y.,Somers, D.; The discovery and initial optimisation of pyrrole-2-carboxamides as inhibitors of p38alpha MAP kinase.; Bioorg.Med.Chem.Lett., 20:3936-3940, 2010; PubMed: 20570148; DOI: 10.1016/j.bmcl.2010.05.011

実験手法

X-RAY DIFFRACTION (1.89 Å)