3MNV

Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment

Summary for 3MNV

• Entry DOI: 10.2210/pdb3mnv/pdb
• Related: 3MNW 3MNZ 3MO1 3MOA 3MOB 3MOD
• Descriptor: ANTI-HIV-1 ANTIBODY 13H11 LIGHT CHAIN, ANTI-HIV-1 ANTIBODY 13H11 HEAVY CHAIN, SULFATE ION, ... (7 entities in total)
• Functional Keywords: hiv-1, hiv, gp41, mper, 13h11, 2f5, z13, 4e10, fab antibody, immune system
• Biological source: Mus musculus (mouse,human); More
• Total number of polymer chains: 4
• Total formula weight: 97404.15

Authors

Nicely, N.I.,Dennison, S.M.,Kelsoe, G.,Liao, H.-X.,Alam, S.M.,Haynes, B.F. (deposition date: 2010-04-22, release date: 2010-11-17, Last modification date: 2023-09-06)

Primary citation

Nicely, N.I.,Dennison, S.M.,Spicer, L.,Scearce, R.M.,Kelsoe, G.,Ueda, Y.,Chen, H.,Liao, H.X.,Alam, S.M.,Haynes, B.F.
Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.
Nat.Struct.Mol.Biol., 17:1492-1494, 2010

PubMed Abstract: The monoclonal antibody 13H11 shares part of its epitope in the HIV-1 gp41 membrane-proximal external region (MPER) with the rare, broadly neutralizing human antibody 2F5. Although 13H11 partially cross-blocked 2F5 binding, 13H11 is non-neutralizing and does not block 2F5 neutralization. We show that unlike 2F5, 13H11 binds to a well-defined helical MPER structure that is consistent with the structure of gp41 in a post-fusion six-helix bundle conformation.

PubMed: 21076400
DOI: 10.1038/nsmb.1944

Experimental method

X-RAY DIFFRACTION (2.4 Å)