3ML3

Crystal structure of the IcsA autochaperone region

Summary for 3ML3

Entry DOI	10.2210/pdb3ml3/pdb
Descriptor	Outer membrane protein icsA autotransporter (2 entities in total)
Functional Keywords	beta helix, beta sandwich, protein transport
Biological source	Shigella flexneri
Cellular location	Outer membrane protein IcsA autotransporter: Periplasm. Outer membrane protein IcsA: Secreted. Outer membrane protein IcsA translocator: Cell outer membrane; Multi-pass membrane protein (Potential): Q7BCK4
Total number of polymer chains	1
Total formula weight	20242.35
Authors	Diezmann, D.,Kuhnel, K. (deposition date: 2010-04-16, release date: 2011-03-02, Last modification date: 2024-03-20)
Primary citation	Kuhnel, K.,Diezmann, D. Crystal Structure of the Autochaperone Region from the Shigella flexneri Autotransporter IcsA J.Bacteriol., 193:2042-2045, 2011 Cited by PubMed Abstract: The IcsA (intracellular spread gene A) autotransporter from Shigella flexneri is a key virulence factor. We identified a stable fragment comprising residues 591 to 758, which corresponds to the autochaperone region of the IcsA passenger domain. We showed that thermal unfolding of the autochaperone region is reversible and determined its crystal structure at 2.0-Å resolution. PubMed: 21335457 DOI: 10.1128/JB.00790-10 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation