3ML3

Crystal structure of the IcsA autochaperone region

3ML3 の概要

• エントリーDOI: 10.2210/pdb3ml3/pdb
• 分子名称: Outer membrane protein icsA autotransporter (2 entities in total)
• 機能のキーワード: beta helix, beta sandwich, protein transport
• 由来する生物種: Shigella flexneri
• 細胞内の位置: Outer membrane protein IcsA autotransporter: Periplasm. Outer membrane protein IcsA: Secreted. Outer membrane protein IcsA translocator: Cell outer membrane; Multi-pass membrane protein (Potential): Q7BCK4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20242.35

構造登録者

Diezmann, D.,Kuhnel, K. (登録日: 2010-04-16, 公開日: 2011-03-02, 最終更新日: 2024-03-20)

主引用文献

Kuhnel, K.,Diezmann, D.
Crystal Structure of the Autochaperone Region from the Shigella flexneri Autotransporter IcsA
J.Bacteriol., 193:2042-2045, 2011

PubMed Abstract: The IcsA (intracellular spread gene A) autotransporter from Shigella flexneri is a key virulence factor. We identified a stable fragment comprising residues 591 to 758, which corresponds to the autochaperone region of the IcsA passenger domain. We showed that thermal unfolding of the autochaperone region is reversible and determined its crystal structure at 2.0-Å resolution.

PubMed: 21335457
DOI: 10.1128/JB.00790-10

実験手法

X-RAY DIFFRACTION (2 Å)