3MKS

Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2

Summary for 3MKS

Entry DOI	10.2210/pdb3mks/pdb
Related	1NEX
Descriptor	Suppressor of kinetochore protein 1, Cell division control protein 4, SULFATE ION, ... (6 entities in total)
Functional Keywords	ubiquitin ligase, protein binding, small molecule complex, ligase/cell cycle, ligase-cell cycle complex
Biological source	Saccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast) More
Total number of polymer chains	4
Total formula weight	146224.45
Authors	Orlicky, S.,Sicheri, F.,Tyers, M.,Tang, X. (deposition date: 2010-04-15, release date: 2010-07-21, Last modification date: 2023-09-06)
Primary citation	Orlicky, S.,Tang, X.,Neduva, V.,Elowe, N.,Brown, E.D.,Sicheri, F.,Tyers, M. An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat.Biotechnol., 28:733-737, 2010 Cited by PubMed: 20581844 DOI: 10.1038/nbt.1646 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation