3MKS
Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2
Summary for 3MKS
Entry DOI | 10.2210/pdb3mks/pdb |
Related | 1NEX |
Descriptor | Suppressor of kinetochore protein 1, Cell division control protein 4, SULFATE ION, ... (6 entities in total) |
Functional Keywords | ubiquitin ligase, protein binding, small molecule complex, ligase/cell cycle, ligase-cell cycle complex |
Biological source | Saccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast) More |
Total number of polymer chains | 4 |
Total formula weight | 146224.45 |
Authors | Orlicky, S.,Sicheri, F.,Tyers, M.,Tang, X. (deposition date: 2010-04-15, release date: 2010-07-21, Last modification date: 2023-09-06) |
Primary citation | Orlicky, S.,Tang, X.,Neduva, V.,Elowe, N.,Brown, E.D.,Sicheri, F.,Tyers, M. An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat.Biotechnol., 28:733-737, 2010 Cited by PubMed: 20581844DOI: 10.1038/nbt.1646 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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