3MHC
Crystal structure of human cabonic anhydrase II in adduct with an adamantyl analogue of acetazolamide in a novel hydrophobic binding pocket
Summary for 3MHC
Entry DOI | 10.2210/pdb3mhc/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, (3S,5S,7S)-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)tricyclo[3.3.1.1~3,7~]decane-1-carboxamide, ... (4 entities in total) |
Functional Keywords | carbonic anhydrase inhibitors, adamantyl, acetazolamide, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29696.91 |
Authors | Avvaru, B.S. (deposition date: 2010-04-07, release date: 2010-07-21, Last modification date: 2023-09-06) |
Primary citation | Avvaru, B.S.,Wagner, J.M.,Maresca, A.,Scozzafava, A.,Robbins, A.H.,Supuran, C.T.,McKenna, R. Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorg.Med.Chem.Lett., 20:4376-4381, 2010 Cited by PubMed: 20605094DOI: 10.1016/j.bmcl.2010.06.082 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.698 Å) |
Structure validation
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