3MHA

Crystal structure of LprG from Mycobacterium tuberculosis bound to PIM

3MHA の概要

• エントリーDOI: 10.2210/pdb3mha/pdb
• 関連するPDBエントリー: 3MH8 3MH9
• 分子名称: Lipoprotein lprG, (1S,2R,3R,4S,5R,6S)-2-(alpha-L-allopyranosyloxy)-3,4,5-trihydroxy-6-({6-O-[(1R)-1-hydroxyhexadecyl]-beta-L-gulopyranosyl}oxy)cyclohexyl (2R)-2-{[(1S)-1-hydroxyhexadecyl]oxy}-3-{[(1S,10S)-1-hydroxy-10-methyloctadecyl]oxy}propyl hydrogen (R)-phosphate (3 entities in total)
• 機能のキーワード: lipoprotein, lprg, glycolipid binding protein, lipid binding protein, structural genomics, tb structural genomics consortium, tbsgc
• 由来する生物種: Mycobacterium tuberculosis
• 細胞内の位置: Cell membrane; Lipid-anchor: P0A5I8
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44351.73

構造登録者

Tsai, H.-C.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (登録日: 2010-04-07, 公開日: 2010-09-01, 最終更新日: 2023-09-06)

• 主引用文献: Drage, M.G.,Tsai, H.C.,Pecora, N.D.,Cheng, T.Y.,Arida, A.R.,Shukla, S.,Rojas, R.E.,Seshadri, C.,Moody, D.B.,Boom, W.H.,Sacchettini, J.C.,Harding, C.V.; Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.; Nat.Struct.Mol.Biol., 17:1088-1095, 2010; PubMed: 20694006; DOI: 10.1038/nsmb.1869

実験手法

X-RAY DIFFRACTION (1.85 Å)