3ME3

Activator-Bound Structure of Human Pyruvate Kinase M2

Summary for 3ME3

• Entry DOI: 10.2210/pdb3me3/pdb
• Descriptor: Pyruvate kinase isozymes M1/M2, 3-{[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl}aniline, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (6 entities in total)
• Functional Keywords: activator, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 242852.19

Authors

Hong, B.,Dimov, S.,Tempel, W.,Auld, D.,Thomas, C.,Boxer, M.,Jianq, J.-K.,Skoumbourdis, A.,Min, S.,Southall, N.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Inglese, J.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2010-03-31, release date: 2010-04-28, Last modification date: 2023-09-06)

• Primary citation: Anastasiou, D.,Yu, Y.,Israelsen, W.J.,Jiang, J.K.,Boxer, M.B.,Hong, B.S.,Tempel, W.,Dimov, S.,Shen, M.,Jha, A.,Yang, H.,Mattaini, K.R.,Metallo, C.M.,Fiske, B.P.,Courtney, K.D.,Malstrom, S.,Khan, T.M.,Kung, C.,Skoumbourdis, A.P.,Veith, H.,Southall, N.,Walsh, M.J.,Brimacombe, K.R.,Leister, W.,Lunt, S.Y.,Johnson, Z.R.,Yen, K.E.,Kunii, K.,Davidson, S.M.,Christofk, H.R.,Austin, C.P.,Inglese, J.,Harris, M.H.,Asara, J.M.,Stephanopoulos, G.,Salituro, F.G.,Jin, S.,Dang, L.,Auld, D.S.,Park, H.W.,Cantley, L.C.,Thomas, C.J.,Vander Heiden, M.G.; Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.; Nat.Chem.Biol., 8:839-847, 2012; PubMed: 22922757; DOI: 10.1038/nchembio.1060

Experimental method

X-RAY DIFFRACTION (1.95 Å)