3MB7

Human CK2 catalytic domain in complex with a difurane derivative inhibitor (AMR)

3MB7 の概要

• エントリーDOI: 10.2210/pdb3mb7/pdb
• 関連するPDBエントリー: 3MB6
• 分子名称: Casein kinase II subunit alpha, naphtho[2,1-b:7,8-b']difuran-2,9-dicarboxylic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinases, difurane, inhibitor, ck2, atp-binding, kinase, nucleotide-binding, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40138.58

構造登録者

Reiser, J.-B.,Prudent, R.,Cochet, C. (登録日: 2010-03-25, 公開日: 2010-05-05, 最終更新日: 2023-09-06)

• 主引用文献: Lopez-Ramos, M.,Prudent, R.,Moucadel, V.,Sautel, C.F.,Barette, C.,Lafanechere, L.,Mouawad, L.,Grierson, D.,Schmidt, F.,Florent, J.C.,Filippakopoulos, P.,Bullock, A.N.,Knapp, S.,Reiser, J.B.,Cochet, C.; New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.; Faseb J., 24:3171-3185, 2010; PubMed: 20400536; DOI: 10.1096/fj.09-143743

実験手法

X-RAY DIFFRACTION (1.65 Å)