3M5O
Crystal structure of HCV NS3/4A protease in complex with N-terminal product 5A5B
Summary for 3M5O
Entry DOI | 10.2210/pdb3m5o/pdb |
Related | 3M5L 3M5M 3M5N |
Descriptor | NS3/4A, TEDVVCC peptide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | hcv, hepatitis c virus, ns3, protease, drug resistance, serine protease, chimera protein, fusion protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Hepatitis C virus subtype 1a More |
Cellular location | Virion : A8DG50 A8DG50 |
Total number of polymer chains | 4 |
Total formula weight | 44789.35 |
Authors | Schiffer, C.A.,Romano, K.P. (deposition date: 2010-03-12, release date: 2010-11-24, Last modification date: 2017-08-09) |
Primary citation | Romano, K.P.,Ali, A.,Royer, W.E.,Schiffer, C.A. Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding. Proc.Natl.Acad.Sci.USA, 107:20986-20991, 2010 Cited by PubMed: 21084633DOI: 10.1073/pnas.1006370107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report