3M3L
PEPA bound to the ligand binding domain of GluA2 (flop form)
Summary for 3M3L
| Entry DOI | 10.2210/pdb3m3l/pdb |
| Related | 3M3F 3M3K |
| Descriptor | Glutamate receptor 2, GLUTAMIC ACID, 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide, ... (5 entities in total) |
| Functional Keywords | glutamate receptor, glur2, glua2, ampa receptor, neurotransmitter receptor, s1s2, allosteric modulator, transport protein |
| Biological source | Rattus norvegicus (Rat) More |
| Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
| Total number of polymer chains | 3 |
| Total formula weight | 88079.26 |
| Authors | Ptak, C.P.,Ahmed, A.H.,Oswald, R.E. (deposition date: 2010-03-09, release date: 2010-03-23, Last modification date: 2023-09-06) |
| Primary citation | Ahmed, A.H.,Ptak, C.P.,Oswald, R.E. Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA. Biochemistry, 49:2843-2850, 2010 Cited by PubMed: 20199107DOI: 10.1021/bi1000678 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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