3M1J

The crystal structure of a NAMI A-Carbonic Anhydrase II adduct discloses the mode of action of this novel anticancer metallodrug

3M1J の概要

• エントリーDOI: 10.2210/pdb3m1j/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, RUTHENIUM ION, ... (7 entities in total)
• 機能のキーワード: ruthenium complexes, nami-a, antimetastatic agents, carbonic anhydrase, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29924.46

構造登録者

Temperini, C.,Messori, L. (登録日: 2010-03-05, 公開日: 2011-01-19, 最終更新日: 2023-11-01)

• 主引用文献: Casini, A.,Temperini, C.,Gabbiani, C.,Supuran, C.T.,Messori, L.; The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins; Chemmedchem, 5:1989-1994, 2010; PubMed: 20931644; DOI: 10.1002/cmdc.201000331

実験手法

X-RAY DIFFRACTION (1.8 Å)