3M18

Crystal structure of variable lymphocyte receptor VLRA.R2.1 in complex with hen egg lysozyme

3M18 の概要

• エントリーDOI: 10.2210/pdb3m18/pdb
• 関連するPDBエントリー: 3M19
• 分子名称: Variable lymphocyte receptor A diversity region, Lysozyme C, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: variable lymphocyte receptor, adaptive immunity, antibody, t cell, b cell, leucine-rich repeat, immune system
• 由来する生物種: Petromyzon marinus (marine lamprey); 詳細
• 細胞内の位置: Secreted: P00698
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 41892.04

構造登録者

Deng, L.,Velikovsky, C.A.,Mariuzza, R.A. (登録日: 2010-03-04, 公開日: 2010-06-30, 最終更新日: 2024-10-09)

主引用文献

Deng, L.,Velikovsky, C.A.,Xu, G.,Iyer, L.M.,Tasumi, S.,Kerzic, M.C.,Flajnik, M.F.,Aravind, L.,Pancer, Z.,Mariuzza, R.A.
A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey.
Proc.Natl.Acad.Sci.USA, 107:13408-13413, 2010

PubMed Abstract: Adaptive immunity in jawless vertebrates is mediated by leucine-rich repeat proteins called "variable lymphocyte receptors" (VLRs). Two types of VLR (A and B) are expressed by mutually exclusive lymphocyte populations in lamprey. VLRB lymphocytes resemble the B cells of jawed vertebrates; VLRA lymphocytes are similar to T cells. We determined the structure of a high-affinity VLRA isolated from lamprey immunized with hen egg white lysozyme (HEL) in unbound and antigen-bound forms. The VLRA-HEL complex demonstrates that certain VLRAs, like gammadelta T-cell receptors (TCRs) but unlike alphabeta TCRs, can recognize antigens directly, without a requirement for processing or antigen-presenting molecules. Thus, these VLRAs feature the nanomolar affinities of antibodies, the direct recognition of unprocessed antigens of both antibodies and gammadelta TCRs, and the exclusive expression on the lymphocyte surface that is unique to alphabeta and gammadelta TCRs.

PubMed: 20616002
DOI: 10.1073/pnas.1005475107

実験手法

X-RAY DIFFRACTION (1.95 Å)