3M17

Crystal structure of human FcRn with a monomeric peptide inhibitor

Summary for 3M17

Entry DOI	10.2210/pdb3m17/pdb
Related	3M1B
Related PRD ID	PRD_001091
Descriptor	IgG receptor FcRn large subunit p51, Beta-2-microglobulin, monomeric peptide inhibitor, ... (4 entities in total)
Functional Keywords	immunoglobulin binding protein, cell membrane, disulfide bond, glycoprotein, igg-binding protein, immunoglobulin domain, membrane, receptor, transmembrane, amyloid, amyloidosis, disease mutation, glycation, immune response, mhc i, pyrrolidone carboxylic acid, secreted, immune system-inhibitor complex, immune system/inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Single-pass type I membrane protein (By similarity): P55899 Secreted: P61769
Total number of polymer chains	12
Total formula weight	172033.55
Authors	Mezo, A.R.,Sridhar, V.,Badger, J.,Sakorafas, P.,Nienaber, V. (deposition date: 2010-03-04, release date: 2010-06-16, Last modification date: 2023-11-22)
Primary citation	Mezo, A.R.,Sridhar, V.,Badger, J.,Sakorafas, P.,Nienaber, V. X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn. J.Biol.Chem., 285:27694-27701, 2010 Cited by PubMed: 20592032 DOI: 10.1074/jbc.M110.120667 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation