3M17

Crystal structure of human FcRn with a monomeric peptide inhibitor

3M17 の概要

• エントリーDOI: 10.2210/pdb3m17/pdb
• 関連するPDBエントリー: 3M1B
• 関連するBIRD辞書のPRD_ID: PRD_001091
• 分子名称: IgG receptor FcRn large subunit p51, Beta-2-microglobulin, monomeric peptide inhibitor, ... (4 entities in total)
• 機能のキーワード: immunoglobulin binding protein, cell membrane, disulfide bond, glycoprotein, igg-binding protein, immunoglobulin domain, membrane, receptor, transmembrane, amyloid, amyloidosis, disease mutation, glycation, immune response, mhc i, pyrrolidone carboxylic acid, secreted, immune system-inhibitor complex, immune system/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein (By similarity): P55899; Secreted: P61769
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 172033.55

構造登録者

Mezo, A.R.,Sridhar, V.,Badger, J.,Sakorafas, P.,Nienaber, V. (登録日: 2010-03-04, 公開日: 2010-06-16, 最終更新日: 2023-11-22)

• 主引用文献: Mezo, A.R.,Sridhar, V.,Badger, J.,Sakorafas, P.,Nienaber, V.; X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn.; J.Biol.Chem., 285:27694-27701, 2010; PubMed: 20592032; DOI: 10.1074/jbc.M110.120667

実験手法

X-RAY DIFFRACTION (2.6 Å)