3M11

Crystal Structure of Aurora A Kinase complexed with inhibitor

Summary for 3M11

Entry DOI	10.2210/pdb3m11/pdb
Descriptor	Serine/threonine-protein kinase 6, 1-(4-{2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea (3 entities in total)
Functional Keywords	aurora kinase inhibitor, x-ray co-crystal analysis, structure-based drug design, atp-binding, cell cycle, cytoskeleton, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains	1
Total formula weight	32884.72
Authors	Wu, J.S.,Leou, J.S.,Coumar, M.S.,Hsieh, H.P.,Wu, S.Y. (deposition date: 2010-03-03, release date: 2011-03-09, Last modification date: 2023-11-01)
Primary citation	Coumar, M.S.,Chu, C.Y.,Lin, C.W.,Shiao, H.Y.,Ho, Y.L.,Reddy, R.,Lin, W.H.,Chen, C.H.,Peng, Y.H.,Leou, J.S.,Lien, T.W.,Huang, C.T.,Fang, M.Y.,Wu, S.H.,Wu, J.S.,Chittimalla, S.K.,Song, J.S.,Hsu, J.T.,Wu, S.Y.,Liao, C.C.,Chao, Y.S.,Hsieh, H.P. Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification J.Med.Chem., 53:4980-4988, 2010 Cited by PubMed: 20550212 DOI: 10.1021/jm1000198 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation