3M11

Crystal Structure of Aurora A Kinase complexed with inhibitor

3M11 の概要

• エントリーDOI: 10.2210/pdb3m11/pdb
• 分子名称: Serine/threonine-protein kinase 6, 1-(4-{2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea (3 entities in total)
• 機能のキーワード: aurora kinase inhibitor, x-ray co-crystal analysis, structure-based drug design, atp-binding, cell cycle, cytoskeleton, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32884.72

構造登録者

Wu, J.S.,Leou, J.S.,Coumar, M.S.,Hsieh, H.P.,Wu, S.Y. (登録日: 2010-03-03, 公開日: 2011-03-09, 最終更新日: 2023-11-01)

• 主引用文献: Coumar, M.S.,Chu, C.Y.,Lin, C.W.,Shiao, H.Y.,Ho, Y.L.,Reddy, R.,Lin, W.H.,Chen, C.H.,Peng, Y.H.,Leou, J.S.,Lien, T.W.,Huang, C.T.,Fang, M.Y.,Wu, S.H.,Wu, J.S.,Chittimalla, S.K.,Song, J.S.,Hsu, J.T.,Wu, S.Y.,Liao, C.C.,Chao, Y.S.,Hsieh, H.P.; Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification; J.Med.Chem., 53:4980-4988, 2010; PubMed: 20550212; DOI: 10.1021/jm1000198

実験手法

X-RAY DIFFRACTION (2.75 Å)