3M08

Wild Type Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1

3M08 の概要

• エントリーDOI: 10.2210/pdb3m08/pdb
• 関連するPDBエントリー: 3M09
• 分子名称: Dihydrofolate reductase, 5-(3,4-dimethoxy-5-{(1E)-3-oxo-3-[(1S)-1-propylphthalazin-2(1H)-yl]prop-1-en-1-yl}benzyl)pyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: folate, dhfr, antimicrobial, antibiotic resistance, nadp, one-carbon metabolism, oxidoreductase', oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19762.14

構造登録者

Bourne, C.R.,Barrow, W.W. (登録日: 2010-03-02, 公開日: 2010-07-14, 最終更新日: 2024-02-21)

• 主引用文献: Bourne, C.R.,Barrow, E.W.,Bunce, R.A.,Bourne, P.C.,Berlin, K.D.,Barrow, W.W.; Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1.; Antimicrob.Agents Chemother., 54:3825-3833, 2010; PubMed: 20606069; DOI: 10.1128/AAC.00361-10

実験手法

X-RAY DIFFRACTION (2.014 Å)