3LZB
EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor
3LZB の概要
エントリーDOI | 10.2210/pdb3lzb/pdb |
分子名称 | Epidermal growth factor receptor, N-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide (3 entities in total) |
機能のキーワード | epidermal growth factor kinase domain, multitargeted small molecule kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
タンパク質・核酸の鎖数 | 8 |
化学式量合計 | 291450.65 |
構造登録者 | |
主引用文献 | Fidanze, S.D.,Erickson, S.A.,Wang, G.T.,Mantei, R.,Clark, R.F.,Sorensen, B.K.,Bamaung, N.Y.,Kovar, P.,Johnson, E.F.,Swinger, K.K.,Stewart, K.D.,Zhang, Q.,Tucker, L.A.,Pappano, W.N.,Wilsbacher, J.L.,Wang, J.,Sheppard, G.S.,Bell, R.L.,Davidsen, S.K.,Hubbard, R.D. Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases. Bioorg.Med.Chem.Lett., 20:2452-2455, 2010 Cited by PubMed: 20346655DOI: 10.1016/j.bmcl.2010.03.015 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.7 Å) |
構造検証レポート
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