3LXE

Human Carbonic Anhydrase I in complex with topiramate

3LXE の概要

• エントリーDOI: 10.2210/pdb3lxe/pdb
• 分子名称: Carbonic anhydrase 1, ZINC ION, [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase 1, topiramate, enzyme-inhibitor complex, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00915
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58359.52

構造登録者

Alterio, V.,De Simone, G.,Monti, S.M.,Truppo, E. (登録日: 2010-02-25, 公開日: 2010-07-21, 最終更新日: 2023-11-01)

• 主引用文献: Alterio, V.,Monti, S.M.,Truppo, E.,Pedone, C.,Supuran, C.T.,De Simone, G.; The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: the carbonic anhydrase I-topiramate complex.; Org.Biomol.Chem., 2010; PubMed: 20505865; DOI: 10.1039/b926832d

実験手法

X-RAY DIFFRACTION (1.9 Å)