3LU6

Human serum albumin in complex with compound 1

Summary for 3LU6

• Entry DOI: 10.2210/pdb3lu6/pdb
• Related: 3LU7 3LU8
• Descriptor: Serum albumin, [(1R,2R)-2-{[(5-fluoro-1H-indol-2-yl)carbonyl]amino}-2,3-dihydro-1H-inden-1-yl]acetic acid (3 entities in total)
• Functional Keywords: binding sites, ligands, protein binding, serum albumin, hsa, proteros biostructures gmbh, transport protein, astrazeneca, drug design
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02768
• Total number of polymer chains: 2
• Total formula weight: 134551.87

Authors

Buttar, D.,Colclough, N.,Gerhardt, S.,MacFaul, P.A.,Phillips, S.D.,Plowright, A.,Whittamore, P.,Tam, K.,Maskos, K.,Steinbacher, S.,Steuber, H. (deposition date: 2010-02-17, release date: 2010-10-27, Last modification date: 2011-07-13)

• Primary citation: Buttar, D.,Colclough, N.,Gerhardt, S.,Macfaul, P.A.,Phillips, S.D.,Plowright, A.,Whittamore, P.,Tam, K.,Maskos, K.,Steinbacher, S.,Steuber, H.; A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions; Bioorg.Med.Chem., 18:7486-7496, 2010; PubMed: 20869876; DOI: 10.1016/j.bmc.2010.08.052

Experimental method

X-RAY DIFFRACTION (2.7 Å)