3LSL

Piracetam bound to the ligand binding domain of GluA2 (flop form)

Summary for 3LSL

Entry DOI	10.2210/pdb3lsl/pdb
Related	3LSF 3LSW 3LSX
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, 2-(2-oxopyrrolidin-1-yl)acetamide, ... (5 entities in total)
Functional Keywords	glutamate receptor, glur2, glua2, ampa receptor, neurotransmitter receptor, s1s2, allosteric modulator, alternative splicing, cell junction, cell membrane, endoplasmic reticulum, glycoprotein, ion transport, ionic channel, membrane, phosphoprotein, postsynaptic cell membrane, receptor, rna editing, synapse, transmembrane, transport, transport protein
Biological source	Rattus norvegicus (brown rat,rat,rats) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	3
Total formula weight	88553.80
Authors	Ahmed, A.H.,Oswald, R.E. (deposition date: 2010-02-12, release date: 2010-03-16, Last modification date: 2023-09-06)
Primary citation	Ahmed, A.H.,Oswald, R.E. Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors. J.Med.Chem., 53:2197-2203, 2010 Cited by PubMed: 20163115 DOI: 10.1021/jm901905j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.122 Å)

Structure validation