Structure of PG16, an antibody with broad and potent neutralization of HIV-1

Summary for 3LRS

DescriptorPG-16 Heavy Chain Fab, PG-16 Light Chain Fab, N-ACETYL-D-GLUCOSAMINE, ... (4 entities in total)
Functional Keywordsneutralizing antibodies, long cdrh3, hiv-1, immune system
Biological sourceHomo sapiens (human)
Total number of polymer chains8
Total molecular weight193219.04
Pancera, M.,Kwong, P.D. (deposition date: 2010-02-11, release date: 2010-06-09, Last modification date: 2017-11-01)
Primary citation
Pancera, M.,McLellan, J.S.,Wu, X.,Zhu, J.,Changela, A.,Schmidt, S.D.,Yang, Y.,Zhou, T.,Phogat, S.,Mascola, J.R.,Kwong, P.D.
Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.
J.Virol., 84:8098-8110, 2010
PubMed: 20538861 (PDB entries with the same primary citation)
DOI: 10.1128/JVI.00966-10
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.247100.2%3.4%2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution