3LRS

Structure of PG16, an antibody with broad and potent neutralization of HIV-1

Summary for 3LRS

• Entry DOI: 10.2210/pdb3lrs/pdb
• Descriptor: PG-16 Heavy Chain Fab, PG-16 Light Chain Fab, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: neutralizing antibodies, long cdrh3, hiv-1, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 193219.04

Authors

Pancera, M.,Kwong, P.D. (deposition date: 2010-02-11, release date: 2010-06-09, Last modification date: 2023-09-06)

• Primary citation: Pancera, M.,McLellan, J.S.,Wu, X.,Zhu, J.,Changela, A.,Schmidt, S.D.,Yang, Y.,Zhou, T.,Phogat, S.,Mascola, J.R.,Kwong, P.D.; Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.; J.Virol., 84:8098-8110, 2010; PubMed: 20538861; DOI: 10.1128/JVI.00966-10

Experimental method

X-RAY DIFFRACTION (2.37 Å)