3LRH
Structure of anti-huntingtin VL domain in complex with huntingtin peptide
Summary for 3LRH
Entry DOI | 10.2210/pdb3lrh/pdb |
Related | 3LRG |
Descriptor | anti-huntingtin VL domain, Huntingtin (3 entities in total) |
Functional Keywords | huntington's disease, huntingtin, variable light chain domain, intrabody, immunoglobulin, immune system |
Biological source | Homo sapiens More |
Cellular location | Cytoplasm: P42858 |
Total number of polymer chains | 16 |
Total formula weight | 116399.78 |
Authors | Schiefner, A.,Chatwell, L.,Skerra, A. (deposition date: 2010-02-11, release date: 2011-02-23, Last modification date: 2023-09-06) |
Primary citation | Schiefner, A.,Chatwell, L.,Korner, J.,Neumaier, I.,Colby, D.W.,Volkmer, R.,Wittrup, K.D.,Skerra, A. A Disulfide-Free Single-Domain V(L) Intrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition. J.Mol.Biol., 414:337-355, 2011 Cited by PubMed: 21968397DOI: 10.1016/j.jmb.2011.09.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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