3LQ8
Structure of the kinase domain of c-Met bound to XL880 (GSK1363089)
Summary for 3LQ8
| Entry DOI | 10.2210/pdb3lq8/pdb |
| Descriptor | Hepatocyte growth factor receptor, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (3 entities in total) |
| Functional Keywords | kinase domain, xl880, gsk1363089, atp-binding, kinase, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase |
| Biological source | Homo sapiens (human) |
| Cellular location | Membrane; Single-pass type I membrane protein: P08581 |
| Total number of polymer chains | 1 |
| Total formula weight | 34834.28 |
| Authors | Lougheed, J.C.,Stout, T.J. (deposition date: 2010-02-08, release date: 2010-05-19, Last modification date: 2024-04-03) |
| Primary citation | Qian, F.,Engst, S.,Yamaguchi, K.,Yu, P.,Won, K.A.,Mock, L.,Lou, T.,Tan, J.,Li, C.,Tam, D.,Lougheed, J.,Yakes, F.M.,Bentzien, F.,Xu, W.,Zaks, T.,Wooster, R.,Greshock, J.,Joly, A.H. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res., 69:8009-8016, 2009 Cited by PubMed: 19808973DOI: 10.1158/0008-5472.CAN-08-4889 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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