3LQ8

Structure of the kinase domain of c-Met bound to XL880 (GSK1363089)

3LQ8 の概要

• エントリーDOI: 10.2210/pdb3lq8/pdb
• 分子名称: Hepatocyte growth factor receptor, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (3 entities in total)
• 機能のキーワード: kinase domain, xl880, gsk1363089, atp-binding, kinase, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34834.28

構造登録者

Lougheed, J.C.,Stout, T.J. (登録日: 2010-02-08, 公開日: 2010-05-19, 最終更新日: 2024-04-03)

• 主引用文献: Qian, F.,Engst, S.,Yamaguchi, K.,Yu, P.,Won, K.A.,Mock, L.,Lou, T.,Tan, J.,Li, C.,Tam, D.,Lougheed, J.,Yakes, F.M.,Bentzien, F.,Xu, W.,Zaks, T.,Wooster, R.,Greshock, J.,Joly, A.H.; Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases.; Cancer Res., 69:8009-8016, 2009; PubMed: 19808973; DOI: 10.1158/0008-5472.CAN-08-4889

実験手法

X-RAY DIFFRACTION (2.02 Å)