3LON

HCV NS3-4a protease domain with ketoamide inhibitor narlaprevir

3LON の概要

• エントリーDOI: 10.2210/pdb3lon/pdb
• 分子名称: Genome polyprotein, KK-NS4a(21-39)-KK, ZINC ION, ... (6 entities in total)
• 機能のキーワード: hepatitis c virus, ns3 protease domain, serine protease, macrocyclic ketoamide inhibitor, hydrolase, atp-binding, capsid protein, envelope protein, helicase, host membrane, membrane, nucleotide-binding, rna replication, transmembrane, virion, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Hepatitis C virus subtype 1a; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 48173.46

構造登録者

Prongay, A.J. (登録日: 2010-02-04, 公開日: 2011-01-19, 最終更新日: 2024-04-03)

• 主引用文献: Arasappan, A.,Bennett, F.,Bogen, S.L.,Blackman, M.,Chen, K.,Hendrata, S.,Huang, Y.,Huelgas, R.M.,Nair, L.,Padilla, A.I.,Pan, W.,Pike, R.,Pinto, P.,Ruan, S.,Sannigrahi, M.,Velaquez, F.,Vibulbhan, B.,Wu, W.,Yang, W.,Saksena, A.K.,Girijavallabhan, V.,Shih, N.Y.,Kong, J.,Meng, T.,Jin, Y.,Wong, J.,McNamara, P.,Prongay, A.,Madison, V.,Piwinski, J.J.,Cheng, K.C.,Morrison, R.,Malcolm, B.,Tong, X.,Ralston, R.,Njoroge, F.G.; Candidate selection and preclinical evaluation culminating in the discovery of Narlaprevir (SCH 900518): A potent, selective and orally efficacious second generation HCV NS3 serine protease inhibitor; To be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)