3LJU

Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3

Summary for 3LJU

Entry DOI	10.2210/pdb3lju/pdb
Descriptor	Arf-GAP with dual PH domain-containing protein 1, ZINC ION, (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, ... (4 entities in total)
Functional Keywords	structural genomics consortium, gap, gtpase activation, sgc, metal-binding, nucleus, phosphoprotein, zinc-finger, hydrolase activator
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O75689
Total number of polymer chains	1
Total formula weight	46718.28
Authors	Shen, L.,Tong, Y.,Tempel, W.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2010-01-26, release date: 2010-11-24, Last modification date: 2023-09-06)
Primary citation	Tong, Y.,Tempel, W.,Wang, H.,Yamada, K.,Shen, L.,Senisterra, G.A.,MacKenzie, F.,Chishti, A.H.,Park, H.W. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. Proc.Natl.Acad.Sci.USA, 107:20346-20351, 2010 Cited by PubMed: 21057110 DOI: 10.1073/pnas.1009008107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.702 Å)

Structure validation