3LJU

Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3

3LJU の概要

• エントリーDOI: 10.2210/pdb3lju/pdb
• 分子名称: Arf-GAP with dual PH domain-containing protein 1, ZINC ION, (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, ... (4 entities in total)
• 機能のキーワード: structural genomics consortium, gap, gtpase activation, sgc, metal-binding, nucleus, phosphoprotein, zinc-finger, hydrolase activator
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O75689
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46718.28

構造登録者

Shen, L.,Tong, Y.,Tempel, W.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H.,Structural Genomics Consortium (SGC) (登録日: 2010-01-26, 公開日: 2010-11-24, 最終更新日: 2023-09-06)

• 主引用文献: Tong, Y.,Tempel, W.,Wang, H.,Yamada, K.,Shen, L.,Senisterra, G.A.,MacKenzie, F.,Chishti, A.H.,Park, H.W.; Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.; Proc.Natl.Acad.Sci.USA, 107:20346-20351, 2010; PubMed: 21057110; DOI: 10.1073/pnas.1009008107

実験手法