3LJ2

IRE1 complexed with JAK Inhibitor I

3LJ2 の概要

• エントリーDOI: 10.2210/pdb3lj2/pdb
• 関連するPDBエントリー: 3LJ0 3LJ1
• 分子名称: Serine/threonine-protein kinase/endoribonuclease IRE1, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE (2 entities in total)
• 機能のキーワード: kinase, kinase inhibitor, nuclease activator, atp-binding, endoplasmic reticulum, glycoprotein, hydrolase, magnesium, membrane, metal-binding, multifunctional enzyme, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transcription, transcription regulation, transferase, transmembrane, unfolded protein response
• 由来する生物種: Saccharomyces cerevisiae (yeast)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type I membrane protein: P32361
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 101175.35

構造登録者

Lee, K.P.K.,Sicheri, F. (登録日: 2010-01-25, 公開日: 2010-05-12, 最終更新日: 2023-09-06)

• 主引用文献: Wiseman, R.L.,Zhang, Y.,Lee, K.P.,Harding, H.P.,Haynes, C.M.,Price, J.,Sicheri, F.,Ron, D.; Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.; Mol.Cell, 38:291-304, 2010; PubMed: 20417606; DOI: 10.1016/j.molcel.2010.04.001

実験手法

X-RAY DIFFRACTION (3.33 Å)