3LIZ

crystal structure of bla g 2 complexed with Fab 4C3

3LIZ の概要

• エントリーDOI: 10.2210/pdb3liz/pdb
• 関連するPDBエントリー: 2NR6
• 分子名称: Aspartic protease Bla g 2, 4C3 monoclonal antibody Light Chain, 4C3 monoclonal antibody Heavy Chain, ... (9 entities in total)
• 機能のキーワード: hydrolase-immune system complex, hydrolase/immune system
• 由来する生物種: Blattella germanica (German cockroach); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 89183.18

構造登録者

Li, M.,Gustchina, A.,Glesner, J.,Wunschmann, S.,Pomes, A.,Wlodawer, A. (登録日: 2010-01-25, 公開日: 2010-12-15, 最終更新日: 2024-11-27)

主引用文献

Glesner, J.,Wunschmann, S.,Li, M.,Gustchina, A.,Wlodawer, A.,Himly, M.,Chapman, M.D.,Pomes, A.
Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding.
Plos One, 6:e22223-e22223, 2011

PubMed Abstract: Cockroach allergy is strongly associated with asthma, and involves the production of IgE antibodies against inhaled allergens. Reports of conformational epitopes on inhaled allergens are limited. The conformational epitopes for two specific monoclonal antibodies (mAb) that interfere with IgE antibody binding were identified by X-ray crystallography on opposite sites of the quasi-symmetrical cockroach allergen Bla g 2.

PubMed: 21789239
DOI: 10.1371/journal.pone.0022223

実験手法

X-RAY DIFFRACTION (1.8 Å)