3LHB

THE 2.7 ANGSTROM CRYSTAL STRUCTURE OF DEOXYGENATED HEMOGLOBIN FROM THE SEA LAMPREY (PETROMYZON MARINUS)

3LHB の概要

• エントリーDOI: 10.2210/pdb3lhb/pdb
• 分子名称: PROTEIN (HEMOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE (2 entities in total)
• 機能のキーワード: hemoglobin, oxygen transport, bohr effect, metal binding protein
• 由来する生物種: Petromyzon marinus (sea lamprey)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 202897.98

構造登録者

Heaslet, H.A.,Royer Jr., W.E. (登録日: 1999-01-12, 公開日: 1999-01-20, 最終更新日: 2023-09-06)

主引用文献

Heaslet, H.A.,Royer Jr., W.E.
The 2.7 A crystal structure of deoxygenated hemoglobin from the sea lamprey (Petromyzon marinus): structural basis for a lowered oxygen affinity and Bohr effect.
Structure Fold.Des., 7:517-526, 1999

PubMed Abstract: The hemoglobins of the sea lamprey are unusual in that cooperativity and sensitivity to pH arise from an equilibrium between a high-affinity monomer and a low-affinity oligomer. Although the crystal structure of the monomeric cyanide derivative has previously been determined, the manner by which oligomerization acts to lower the oxygen affinity and confer a strong Bohr effect has, until now, been speculative.

PubMed: 10378271
DOI: 10.1016/S0969-2126(99)80068-9

実験手法

X-RAY DIFFRACTION (2.7 Å)