3LEA

Crystal structure of the catalytic domain of TACE with Isoindolinone-biphenyl-hydantoin inhibitor

3LEA の概要

• エントリーDOI: 10.2210/pdb3lea/pdb
• 関連するPDBエントリー: 1bkc 3L0T 3L0V 3LE9
• 分子名称: Disintegrin and metalloproteinase domain-containing protein 17, 2-{[(4R)-2,5-dioxo-4-(4-pyridin-3-ylphenyl)imidazolidin-4-yl]methyl}-6-methoxy-1-oxo-1H-isoindolium, ZINC ION, ... (5 entities in total)
• 機能のキーワード: glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, transmembrane, zymogen, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P78536
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62184.05

構造登録者

Orth, P. (登録日: 2010-01-14, 公開日: 2010-12-08, 最終更新日: 2023-09-06)

• 主引用文献: Yu, W.,Tong, L.,Kim, S.H.,Wong, M.K.,Chen, L.,Yang, D.Y.,Shankar, B.B.,Lavey, B.J.,Zhou, G.,Kosinski, A.,Rizvi, R.,Li, D.,Feltz, R.J.,Piwinski, J.J.,Rosner, K.E.,Shih, N.Y.,Siddiqui, M.A.,Guo, Z.,Orth, P.,Shah, H.,Sun, J.,Umland, S.,Lundell, D.J.,Niu, X.,Kozlowski, J.A.; Biaryl substituted hydantoin compounds as TACE inhibitors.; Bioorg.Med.Chem.Lett., 20:5286-5289, 2010; PubMed: 20663669; DOI: 10.1016/j.bmcl.2010.06.134

実験手法

X-RAY DIFFRACTION (2 Å)