3LE6
The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor
3LE6 の概要
エントリーDOI | 10.2210/pdb3le6/pdb |
分子名称 | Cell division protein kinase 2, 5-(2-chlorophenyl)-3-methyl-7-nitropyrazolo[3,4-b][1,4]benzodiazepine (3 entities in total) |
機能のキーワード | cyclin-dependent kinase 2 drug design, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 34328.24 |
構造登録者 | Lukacs, C.M.,Swain, A.,Crowther, R.L.,Kammlott, R.U.,Liu, J.J. (登録日: 2010-01-14, 公開日: 2010-11-17, 最終更新日: 2024-02-21) |
主引用文献 | Liu, J.J.,Daniewski, I.,Ding, Q.,Higgins, B.,Ju, G.,Kolinsky, K.,Konzelmann, F.,Lukacs, C.,Pizzolato, G.,Rossman, P.,Swain, A.,Thakkar, K.,Wei, C.C.,Miklowski, D.,Yang, H.,Yin, X.,Wovkulich, P.M. Pyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors. Bioorg.Med.Chem.Lett., 20:5984-5987, 2010 Cited by PubMed: 20832307DOI: 10.1016/j.bmcl.2010.08.079 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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