3LE6

The structure of cyclin dependent kinase 2 (CKD2) with a pyrazolobenzodiazepine inhibitor

3LE6 の概要

• エントリーDOI: 10.2210/pdb3le6/pdb
• 分子名称: Cell division protein kinase 2, 5-(2-chlorophenyl)-3-methyl-7-nitropyrazolo[3,4-b][1,4]benzodiazepine (3 entities in total)
• 機能のキーワード: cyclin-dependent kinase 2 drug design, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34328.24

構造登録者

Lukacs, C.M.,Swain, A.,Crowther, R.L.,Kammlott, R.U.,Liu, J.J. (登録日: 2010-01-14, 公開日: 2010-11-17, 最終更新日: 2024-02-21)

• 主引用文献: Liu, J.J.,Daniewski, I.,Ding, Q.,Higgins, B.,Ju, G.,Kolinsky, K.,Konzelmann, F.,Lukacs, C.,Pizzolato, G.,Rossman, P.,Swain, A.,Thakkar, K.,Wei, C.C.,Miklowski, D.,Yang, H.,Yin, X.,Wovkulich, P.M.; Pyrazolobenzodiazepines: part I. Synthesis and SAR of a potent class of kinase inhibitors.; Bioorg.Med.Chem.Lett., 20:5984-5987, 2010; PubMed: 20832307; DOI: 10.1016/j.bmcl.2010.08.079

実験手法

X-RAY DIFFRACTION (2 Å)