3LCP
Crystal structure of the carbohydrate recognition domain of LMAN1 in complex with MCFD2
Summary for 3LCP
Entry DOI | 10.2210/pdb3lcp/pdb |
Descriptor | Protein ERGIC-53, Multiple coagulation factor deficiency protein 2, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | er-golgi transport, glycoprotein sorting, disease mutation, secretory pathway, protein transport, coagulation factor deficiency, disulfide bond, endoplasmic reticulum, golgi apparatus, lectin, membrane, polymorphism, transmembrane, transport, calcium, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein: P49257 Endoplasmic reticulum-Golgi intermediate compartment: Q8NI22 |
Total number of polymer chains | 4 |
Total formula weight | 75511.93 |
Authors | Wigren, E.,Bourhis, J.M.,Kursula, I.,Guy, J.E.,Lindqvist, Y. (deposition date: 2010-01-11, release date: 2010-01-26, Last modification date: 2023-09-06) |
Primary citation | Wigren, E.,Bourhis, J.M.,Kursula, I.,Guy, J.E.,Lindqvist, Y. Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII. Febs Lett., 584:878-882, 2010 Cited by PubMed: 20138881DOI: 10.1016/j.febslet.2010.02.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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