3LCP

Crystal structure of the carbohydrate recognition domain of LMAN1 in complex with MCFD2

3LCP の概要

• エントリーDOI: 10.2210/pdb3lcp/pdb
• 分子名称: Protein ERGIC-53, Multiple coagulation factor deficiency protein 2, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: er-golgi transport, glycoprotein sorting, disease mutation, secretory pathway, protein transport, coagulation factor deficiency, disulfide bond, endoplasmic reticulum, golgi apparatus, lectin, membrane, polymorphism, transmembrane, transport, calcium, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein: P49257; Endoplasmic reticulum-Golgi intermediate compartment: Q8NI22
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 75511.93

構造登録者

Wigren, E.,Bourhis, J.M.,Kursula, I.,Guy, J.E.,Lindqvist, Y. (登録日: 2010-01-11, 公開日: 2010-01-26, 最終更新日: 2023-09-06)

• 主引用文献: Wigren, E.,Bourhis, J.M.,Kursula, I.,Guy, J.E.,Lindqvist, Y.; Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII.; Febs Lett., 584:878-882, 2010; PubMed: 20138881; DOI: 10.1016/j.febslet.2010.02.009

実験手法

X-RAY DIFFRACTION (2.45 Å)