3LCE
Crystal Structure of Oxa-10 Beta-Lactamase Covalently Bound to Cyclobutanone Beta-Lactam Mimic
Summary for 3LCE
Entry DOI | 10.2210/pdb3lce/pdb |
Descriptor | Beta-lactamase OXA-10, GLYCEROL, (1S,3S,4S,5S)-7,7-dichloro-3-methoxy-2-thiabicyclo[3.2.0]heptan-6-one-4-carboxylic acid, ... (5 entities in total) |
Functional Keywords | beta-lactamase, beta-lactamase inhibitor, beta-lactam mimic, cyclobutanone, hemiketal, antibiotic resistance, disulfide bond, hydrolase, plasmid, transposable element |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 4 |
Total formula weight | 112014.38 |
Authors | Gretes, M.,Strynadka, N.C.J. (deposition date: 2010-01-10, release date: 2010-03-09, Last modification date: 2023-11-22) |
Primary citation | Johnson, J.W.,Gretes, M.,Goodfellow, V.J.,Marrone, L.,Heynen, M.L.,Strynadka, N.C.,Dmitrienko, G.I. Cyclobutanone Analogues of beta-Lactams Revisited: Insights into Conformational Requirements for Inhibition of Serine- and Metallo-beta-Lactamases. J.Am.Chem.Soc., 132:2558-2560, 2010 Cited by PubMed: 20141132DOI: 10.1021/ja9086374 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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