3LCE

Crystal Structure of Oxa-10 Beta-Lactamase Covalently Bound to Cyclobutanone Beta-Lactam Mimic

3LCE の概要

• エントリーDOI: 10.2210/pdb3lce/pdb
• 分子名称: Beta-lactamase OXA-10, GLYCEROL, (1S,3S,4S,5S)-7,7-dichloro-3-methoxy-2-thiabicyclo[3.2.0]heptan-6-one-4-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: beta-lactamase, beta-lactamase inhibitor, beta-lactam mimic, cyclobutanone, hemiketal, antibiotic resistance, disulfide bond, hydrolase, plasmid, transposable element
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 112014.38

構造登録者

Gretes, M.,Strynadka, N.C.J. (登録日: 2010-01-10, 公開日: 2010-03-09, 最終更新日: 2023-11-22)

• 主引用文献: Johnson, J.W.,Gretes, M.,Goodfellow, V.J.,Marrone, L.,Heynen, M.L.,Strynadka, N.C.,Dmitrienko, G.I.; Cyclobutanone Analogues of beta-Lactams Revisited: Insights into Conformational Requirements for Inhibition of Serine- and Metallo-beta-Lactamases.; J.Am.Chem.Soc., 132:2558-2560, 2010; PubMed: 20141132; DOI: 10.1021/ja9086374

実験手法

X-RAY DIFFRACTION (2 Å)