3LC5
Selective Benzothiophine Inhibitors of Factor IXa
Summary for 3LC5
Entry DOI | 10.2210/pdb3lc5/pdb |
Related | 3LC3 |
Descriptor | Coagulation factor IX, CALCIUM ION, 1-{4-[(R)-phenyl(3-phenyl-1,2,4-oxadiazol-5-yl)methoxy]-1-benzothiophen-2-yl}methanediamine, ... (5 entities in total) |
Functional Keywords | protein-inhibitor complex, peptidase s1, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, disulfide bond, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hemophilia, hydrolase, hydroxylation, pharmaceutical, phosphoprotein, polymorphism, protease, secreted, serine protease, sulfation, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00740 P00740 |
Total number of polymer chains | 2 |
Total formula weight | 32915.54 |
Authors | |
Primary citation | Wang, S.,Beck, R.,Burd, A.,Blench, T.,Marlin, F.,Ayele, T.,Buxton, S.,Dagostin, C.,Malic, M.,Joshi, R.,Barry, J.,Sajad, M.,Cheung, C.,Shaikh, S.,Chahwala, S.,Chander, C.,Baumgartner, C.,Holthoff, H.P.,Murray, E.,Blackney, M.,Giddings, A. Structure Based Drug Design: Development of Potent and Selective Factor IXa (FIXa) Inhibitors. J.Med.Chem., 53:1473-1482, 2010 Cited by PubMed: 20121197DOI: 10.1021/jm901476x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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