3LC5

Selective Benzothiophine Inhibitors of Factor IXa

3LC5 の概要

• エントリーDOI: 10.2210/pdb3lc5/pdb
• 関連するPDBエントリー: 3LC3
• 分子名称: Coagulation factor IX, CALCIUM ION, 1-{4-[(R)-phenyl(3-phenyl-1,2,4-oxadiazol-5-yl)methoxy]-1-benzothiophen-2-yl}methanediamine, ... (5 entities in total)
• 機能のキーワード: protein-inhibitor complex, peptidase s1, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, disulfide bond, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hemophilia, hydrolase, hydroxylation, pharmaceutical, phosphoprotein, polymorphism, protease, secreted, serine protease, sulfation, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00740 P00740
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32915.54

構造登録者

Wang, S.,Beck, R. (登録日: 2010-01-09, 公開日: 2010-02-23, 最終更新日: 2011-07-13)

• 主引用文献: Wang, S.,Beck, R.,Burd, A.,Blench, T.,Marlin, F.,Ayele, T.,Buxton, S.,Dagostin, C.,Malic, M.,Joshi, R.,Barry, J.,Sajad, M.,Cheung, C.,Shaikh, S.,Chahwala, S.,Chander, C.,Baumgartner, C.,Holthoff, H.P.,Murray, E.,Blackney, M.,Giddings, A.; Structure Based Drug Design: Development of Potent and Selective Factor IXa (FIXa) Inhibitors.; J.Med.Chem., 53:1473-1482, 2010; PubMed: 20121197; DOI: 10.1021/jm901476x

実験手法

X-RAY DIFFRACTION (2.62 Å)