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3LC3

Benzothiophene Inhibitors of Factor IXa

Summary for 3LC3
Entry DOI10.2210/pdb3lc3/pdb
Related3LC5
DescriptorCoagulation factor IX, 1-[5-(3,4-dimethoxyphenyl)-1-benzothiophen-2-yl]methanediamine, CALCIUM ION, ... (5 entities in total)
Functional Keywordsprotein-inhibitor complex, peptidase s1, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, disulfide bond, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hemophilia, hydrolase, hydroxylation, pharmaceutical, phosphoprotein, polymorphism, protease, secreted, serine protease, sulfation, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P00740 P00740
Total number of polymer chains4
Total formula weight66231.67
Authors
Wang, S.,Beck, R. (deposition date: 2010-01-09, release date: 2010-02-23, Last modification date: 2011-07-13)
Primary citationWang, S.,Beck, R.,Blench, T.,Burd, A.,Buxton, S.,Malic, M.,Ayele, T.,Shaikh, S.,Chahwala, S.,Chander, C.,Holland, R.,Merette, S.,Zhao, L.,Blackney, M.,Watts, A.
Studies of Benzothiophene Template as Potent Factor IXa (FIXa) Inhibitors in Thrombosis.
J.Med.Chem., 53:1465-1472, 2010
Cited by
PubMed: 20121198
DOI: 10.1021/jm901475e
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

数据于2024-03-27公开中

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